Elucidation of the Rotavirus NSP4-Caveolin-1 and -Cholesterol Interactions Using Synthetic Peptides
نویسندگان
چکیده
منابع مشابه
Elucidation of the Rotavirus NSP4-Caveolin-1 and -Cholesterol Interactions Using Synthetic Peptides
Rotavirus (RV) NSP4, the first described viral enterotoxin, is a multifunctional glycoprotein that contributes to viral pathogenesis, morphogenesis, and replication. NSP4 binds both termini of caveolin-1 and is isolated from caveolae fractions that are rich in anionic phospholipids and cholesterol. These interactions indicate that cholesterol/caveolin-1 plays a role in NSP4 transport to the cel...
متن کاملThe rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1.
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15 صفحه اولInteraction(s) of rotavirus non-structural protein 4 (NSP4) C-terminal peptides with model membranes.
Rotavirus is the major cause of dehydrating gastroenteritis in children and young animals. NSP4 (non-structural protein 4), a rotaviral non-structural glycoprotein and a peptide NSP4(114-135) (DKLTTREIEQVELLKRIYDKLT), corresponding to NSP4 amino acids 114-135, induce diarrhoeal disease in a neonatal mouse model and interact with model membranes that mimic caveolae. Correlation of the mechanisms...
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ژورنال
عنوان ژورنال: Journal of Amino Acids
سال: 2012
ISSN: 2090-0104,2090-0112
DOI: 10.1155/2012/575180